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Search Results for " 3cl protease "

Targets Recommended: SARS-CoV

25

抑制剂 & 化合物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60045	NK01-63 NK01 63	SARS-CoV	Microbiology/Virology
	NK01-63 (Coronastat) 是SARS-CoV-2 3CL 蛋白酶的有效抑制剂。
T9716	Ensitrelvir S-217622	SARS-CoV	Microbiology/Virology
	Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂，IC50为13 nM。
T9574	PF-07304814 Lufotrelvir,卢夫特韦
	Lufotrelvir (PF-07304814) 是 PF-00835231 的磷酸盐前药，是一种有效的3CLpro 蛋白酶 (Mpro) 抑制剂，具有抗SARS-CoV-2 病毒活性。Lufotrelvir 结合并抑制 SARS-CoV-2 3CLpro 活性，Ki 为 174nM。Lufotrelvir 是一种很有前途的单一抗病毒试剂，也可用于与针对冠状病毒生命周期其他关键阶段的其他抗病毒试剂的联合研究。
T6738	Z-FA-FMK	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒蛋白酶3CL，Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶，也可以抑制效应半胱天冬酶。
T69841	GC813 sodium
	GC813 is a potent and permeable inhibitor of MERS coronavirus 3CL protease. GC813 is analogue of GC376.
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.
T72371	SARS-CoV-2 3CLpro-IN-7
	SARS-CoV-2 3CLpro-IN-7 是一种可逆的共价SARS-CoV-2 3CL 蛋白酶抑制剂，IC50值为 1.4 µM。
T82622	D1N8	SARS-CoV	Microbiology/Virology
	D1N8是一种针对SARS-CoV-2 3CLpro的有效抑制剂，其IC50值为0.44 μM，CC50值大于20 μM。它具备作为针对3CLpro的SARS-CoV-2抗病毒药物研究潜力。
T79867	Ibuzatrelvir PF-07817883	Virus Protease	Microbiology/Virology
	Ibuzatrelvir (PF-07817883) 是针对 SARS-CoV-2 3CL 蛋白酶的抗病毒剂，能够用于抑制 COVID-19。
T63385	SARS-CoV-2 3CLpro-IN-2
	SARS-CoV-2 3CLpro-IN-2 是 3CL 蛋白酶对有效抑制剂，对SARS-CoV-2疾病表现出研究潜力。
T79866	Zevotrelvir	SARS-CoV	Microbiology/Virology
	Zevotrelvir (化合物 52)作为冠状病毒抑制剂，对229E hCoV及SARS-CoV-3CL proteases展现出的IC50值均为 <0.1 μM和 <0.1 mM。此化合物显示了对病毒感染治疗的潜在应用。
T79660	SARS-CoV-2 3CLpro-IN-17	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-17 (Compound 3h)为选择性SARS-CoV-2 3CLpro抑制剂，具有0.322μM的IC50s值。
T82623	D1N52	SARS-CoV	Microbiology/Virology
	D1N52为一高效SARS-CoV-2 3CLpro抑制剂，具IC50值0.53 μM。
T61774	SARS 3CLpro-IN-1
	SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1].
T74807	SARS-CoV-2 3CLpro-IN-13
	SARS-CoV-2 3CLpro-IN-13是一种针对SARS-CoV-2 3CL蛋白酶抑制剂，表现出有效的抗冠状病毒活性，其IC50值达21 nM。
T73052	Pomotrelvir PBI-0451
	Pomotrelvir (PBI-0451)是一种选择性的、具有口服活性的 SARS-CoV-23CL 蛋白酶抑制剂。Pomotrelvir 具有抗病毒活性，可用于新型冠状病毒（COVID-19）研究。
T72370	SARS-CoV-2 3CLpro-IN-6
	SARS-CoV-2 3CLpro-IN-6 是 SARS-CoV-2 3CL 蛋白酶的可逆共价抑制剂。SARS-CoV-2 3CLpro-IN-6 对 SARS-CoV-2 3CLpro 具有强效抑制活性，IC50值为 4.9 μM。SARS-CoV-2 3CLpro-IN-6 可用于 COVID-19 的研究。
T40358	Ensitrelvir fumarate S-217622 fumarate
	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
T79218	SARS-CoV-2-IN-41	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-41（compound 2）作为SARS-CoV-2 3CLpro的抑制剂，其IC50值达到0.022 µM，表现出明显的抗病毒活性。
T72312	SARS-CoV-2 3CLpro-IN-10
	SARS-CoV-2 3CLpro-IN-10(5d)为一种有效的抗 SARS-CoV-2 3CL 蛋白酶抑制剂，其IC50值仅为190 nM，同时对SARS-CoV-1的IC50值为790 nM，对MERS-CoV的IC50值则为70 nM，显示出广谱的抗病毒活性。
T80657	SARS-CoV-2 3CLpro-IN-15	Virus Protease	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-15（compound a）为β-硝基苯乙烯型抑制剂，专门针对SARS-CoV-2的3CL蛋白酶（3CLpro）而设计。该化合物能有效抑制病毒的复制转录过程，是研发抗COVID-19候选先导化合物的关键因素。
T72313	SARS-CoV-2 3CLpro-IN-11
	SARS-CoV-2 3CLpro-IN-11(11d)为一种针对SARS-CoV-2 3CL蛋白酶的有效抑制剂，具备IC50值140 nM，并对SARS-CoV-1和MERS-CoV分别展现出IC50值240 nM与70 nM的抑制活性，显示出其广谱的抗病毒能力。
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T78119	Z-L(D-Val)G-CHN2	HSV	Microbiology/Virology
	Z-L(D-Val)G-CHN2（即Z-LVG-CHN2）是半胱氨酸蛋白酶抑制剂的异构体，作为一种三肽衍生物，模仿了人体半胱氨酸蛋白酶结合中心的部分结构。它可以抑制HSV，并且能有效阻断SARS-COV-2的3CL pro蛋白酶，从而抑制病毒活性（EC50=190 nM），但对脊髓灰质炎病毒复制无显著作用。
T73898	Paritaprevir dihydrate
	Paritaprevir (ABT-450) dihydrate，一种口服非结构蛋白3/4A (NS3/4A) 蛋白酶抑制剂，对HCV1a 和 1b 具有高效抗病毒活性，EC50值分别为1 nM 和 0.21 nM。此外，其作为SARS-CoV3CLpro 抑制剂，IC50为1.31 μM。其主要通过细胞色素P450 (CYP) 3A代谢，且利托那韦 (Ritonavir，CYP450 抑制剂) 能增强其血浆浓度和延长半衰期。

化合物

Cat.No: T60045

Synonym: NK01 63

Target: SARS-CoV

Cat.No: T9716

Synonym: S-217622

Target: SARS-CoV

Cat.No: T9574

Synonym: Lufotrelvir,卢夫特韦

Cat.No: T6738

Target: SARS-CoV, Cysteine Protease

Cat.No: T69841

SARS-CoV-2-IN-10

Cat.No: T40340

SARS-CoV-2 3CLpro-IN-7

Cat.No: T72371

Cat.No: T82622

Target: SARS-CoV

Cat.No: T79867

Synonym: PF-07817883

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-2

Cat.No: T63385

Cat.No: T79866

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-17

Cat.No: T79660

Target: SARS-CoV

Cat.No: T82623

Target: SARS-CoV

SARS 3CLpro-IN-1

Cat.No: T61774

SARS-CoV-2 3CLpro-IN-13

Cat.No: T74807

Cat.No: T73052

Synonym: PBI-0451

SARS-CoV-2 3CLpro-IN-6

Cat.No: T72370

Ensitrelvir fumarate

Cat.No: T40358

Synonym: S-217622 fumarate

SARS-CoV-2-IN-41

Cat.No: T79218

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-10

Cat.No: T72312

SARS-CoV-2 3CLpro-IN-15

Cat.No: T80657

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-11

Cat.No: T72313

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

Z-L(D-Val)G-CHN2

Cat.No: T78119

Target: HSV

Paritaprevir dihydrate

Cat.No: T73898

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL Protease,	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,Mpro,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL-Mpro,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5kDa and the accession number is YP_009725301.1.
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8kDa and the accession number is YP_009725301.1.
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,3CL	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.78 kDa and the accession number is YP_009725301.1.
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant 3CL-Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Pr...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.8kDa and the accession number is YP_009725301.1.
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.4kDa and the accession number is YP_009725301.1.
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) COVID-19,3CL Protease,M Proteinas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Pr...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.79 kDa and the accession number is YP_009725301.1.
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant 3CL Protease,3CL	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant M Proteinase,3CL-Mpro,Mpro,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.82 kDa and the accession number is YP_009725301.1.
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.72 kDa and the accession number is YP_009725301.1.
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5 kDa and the accession number is YP_009725301.1.
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant M Proteinase,3C-like Proteinase,3CL	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec...
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) M Proteinase,3CL Proteinase	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t...

重组蛋白

3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01335

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant

Cat.No: TMPK-01343

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01344

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant

Cat.No: TMPK-01346

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant

Cat.No: TMPK-01339

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01336

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant

Cat.No: TMPK-01342

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant

Cat.No: TMPK-01347

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)

Cat.No: TMPK-01348

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant

Cat.No: TMPK-01337

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant

Cat.No: TMPK-01341

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant

Cat.No: TMPK-01338

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant

Cat.No: TMPK-01340

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01345

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant

Cat.No: TMPJ-01449

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)

Cat.No: TMPJ-01448

Species: 2019-nCoV

Expression System: E. coli

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